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Learned taste aversion induced by cortical spreading depression.

F J Winn, M A Kent, T M Libkuman

    Physiology & Behavior
    |July 11, 1975
    PubMed
    Summary
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    Cortical spreading depression (CSD) in rats induced a taste aversion to sucrose solutions. This aversion was concentration-dependent and occurred even when the cortex was not essential for learning.

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Physiology

    Background:

    • Water deprivation is a common method to motivate learning in animal studies.
    • Cortical spreading depression (CSD) is a wave of neural excitation followed by inhibition.
    • Previous research suggests CSD may have amnesic properties.

    Purpose of the Study:

    • To investigate the aversive and amnesic properties of cortical spreading depression (CSD).
    • To determine if CSD affects taste aversion learning.
    • To explore the role of cortical concentration and laterality in CSD-induced effects.

    Main Methods:

    • Male albino rats were subjected to a 24-hour water deprivation schedule.
    • Different concentrations of KCl (12% and 25%) or Ringers solution were applied unilaterally or bilaterally to the cortex.

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  • Taste aversion was assessed by offering a choice between sucrose solution and water after CSD induction.

    • Main Results:

    • Only rats receiving unilateral or bilateral 12% KCl developed an aversion to the sucrose solution.
    • A concentration-dependent gradient of CSD's effects was observed.
    • These findings suggest CSD possesses both aversive and amnesic characteristics.

    Conclusions:

    • Cortical spreading depression (CSD) can induce aversive learning, leading to taste aversion.
    • The intensity of CSD's effects on aversion learning is dependent on the concentration of the applied substance.
    • The cortex is not essential for the learning of taste aversion, even in the presence of CSD.