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[Progress in the study of CCN family]
1Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China. subingyin@yahoo.com.cn
Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA
|October 23, 2002
Summary
The CCN gene family, including CTGF and Cyr61, consists of secreted proteins regulating cell growth and differentiation. These proteins are implicated in various biological processes, from development to tumor genesis.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- A novel gene family, termed CCN, has emerged in the last 5-6 years.
- This family currently includes CTGF, Cyr61, nov, elm1, HICP, and WISP-3.
- CCN proteins are secreted and share conserved structural features.
Purpose of the Study:
- To introduce the CCN gene family and its members.
- To describe the structural characteristics of CCN proteins.
- To highlight the diverse biological roles of CCN proteins.
Main Methods:
- Literature review and analysis of existing data on the CCN gene family.
- Bioinformatic analysis of protein structure and conserved domains.
- Review of studies investigating the functions of CCN family members.
Main Results:
- The CCN family comprises secreted proteins with 343-381 amino acids.
- These proteins possess four distinct structural modules with 38 conserved cysteine residues.
- CCN proteins influence cellular behaviors like growth, differentiation, adhesion, and locomotion.
Conclusions:
- CCN proteins are key regulators of fundamental cellular processes.
- The family plays critical roles in physiological and pathological conditions.
- Further research into CCN proteins may yield therapeutic insights for various diseases.