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Early brain atrophy in persistent hyperinsulinemic hypoglycemia of infancy
Zohar Nachum1, Izhar Ben-Shlomo, Yardena Rakover
1Department of Obstetrics and Gynecology, The Pediatric Endocrine Unit and Endocrine Laboratory, HaEmek Medical Center, Afula, Israel.
The Journal of Pediatrics
|November 1, 2002
Abstract:
We present two siblings with persistent hyperinsulinemic hypoglycemia of infancy, accelerated intrauterine growth and early neonatal brain atrophy. Fetal plasma glucose and insulin levels in the second sibling revealed normoglycemia despite hyperinsulinemia. The absence of intrauterine hypoglycemia suggests that the brain damage is not secondary to hypoglycemia and other etiologies must be considered.