Related Experiment Videos
Intralobar pulmonary sequestration presenting increased serum CA19-9 and CA125.
Hisanaga Yagyu1, Hideki Adachi, Kinya Furukawa
1Fifth Department of Internal Medicine, Tokyo Medical University, Inashiki-gun, Ibaraki.
Internal Medicine (Tokyo, Japan)
|November 5, 2002
Summary
Intralobar pulmonary sequestration can cause elevated cancer antigen 19-9 (CA19-9) and cancer antigen 125 (CA125) levels. Surgical resection normalized these tumor marker levels in a patient with this rare congenital lung malformation.
Area of Science:
- Pulmonology
- Surgical Pathology
- Oncology
Background:
- Elevated serum tumor markers like CA19-9 and CA125 can indicate various conditions, including malignancy.
- Pulmonary sequestration is a rare congenital lung malformation where lung tissue does not develop normally and receives its blood supply from an aberrant systemic artery.
Observation:
- A 39-year-old male presented with a lung nodule and significantly elevated CA19-9 and CA125 levels.
- Chest CT revealed a well-defined nodule, and angiography identified an aberrant artery supplying the lesion.
- Microscopic examination of the resected lung showed a mucus-containing, cystically dilated bronchus lined by ciliated cylindrical epithelium.
Findings:
- Immunohistochemical staining confirmed the presence of CA19-9 and CA125 within the ciliated epithelium and mucus of the sequestrated lung.
- The patient was diagnosed with intralobar pulmonary sequestration.
Implications:
- This case highlights intralobar pulmonary sequestration as a potential, albeit rare, cause of elevated CA19-9 and CA125, mimicking malignancy.
- Surgical resection of the sequestrated lung led to the normalization of serum tumor marker levels, suggesting a direct link.
- Consideration of rare congenital lung abnormalities is crucial in the differential diagnosis of unexplained hyper-tumor marker states.