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Structural modification of collagen during nonenzymatic glycosylation in vitro
V V Berzhitskaya1, M V Timofeeva, G A Rebrova
1VILAR Research, Training, and Methodological Center of Biomedical Technologies, Moscow.
Bulletin of Experimental Biology and Medicine
|November 7, 2002
Abstract:
We studied changes in collagen resistance to proteases and formation of new fluorescent compounds during in vitro nonenzymatic glycosylation. The inhibitory effects of guanidine chloride and catalase were different: guanidine chloride inhibited cross-linking in collagen molecules, while catalase inhibited the formation of chromophore-containing compounds.