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Oligodendrogliomas.

W Reiche1, I Grunwald, K Hermann

  • 1Department of Neuroradiology, Radiological Clinic, Saarland University Clinic in Homburg/Saar, Germany.

Acta Radiologica (Stockholm, Sweden : 1987)
|November 9, 2002
PubMed
Summary
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Contrast enhancement on MRI and CT scans can help grade oligodendrogliomas. However, calcifications may affect imaging results, making definitive grading challenging.

Area of Science:

  • Neuro-oncology
  • Radiology
  • Pathology

Background:

  • Oligodendrogliomas are primary brain tumors with varying grades.
  • Accurate grading is crucial for treatment planning and prognosis.
  • Imaging features, including contrast enhancement, are used to assess tumor grade.

Purpose of the Study:

  • To investigate contrast enhancement patterns in Magnetic Resonance (MR) and Computed Tomography (CT) imaging of oligodendrogliomas.
  • To correlate imaging findings with histopathological grading.
  • To compare MR and CT contrast enhancement characteristics.

Main Methods:

  • Retrospective review of 20 patients with oligodendrogliomas (12 WHO grade II, 8 WHO grade III).
  • Analysis of MR imaging, non-enhanced CT, and contrast-enhanced CT studies.

Related Experiment Videos

  • Blind assessment of imaging findings relative to tumor histological grades.

    • Main Results:

    • All anaplastic (WHO III) oligodendrogliomas showed contrast enhancement on both MR and CT.
    • 6/12 low-grade (WHO II) oligodendrogliomas exhibited MR contrast enhancement, with 5 showing calcifications on CT.
    • No significant MR contrast enhancement was observed in the remaining 6/12 WHO grade II cases.
    • Statistical analysis revealed significant correlations between contrast enhancement and tumor grade (p=0.042 for MR, p=0.011 for CT).
    • Combined analysis of tumor grade, CT-detected calcifications, and MR enhancement showed a significant correlation (p=0.014).

    Conclusions:

    • Distinguishing oligodendroglioma grades solely based on MR contrast enhancement is not definitive.
    • Factors beyond tumor neovascularization, such as calcifications, may influence the blood-brain barrier and imaging appearance.
    • Further research is needed to refine imaging criteria for accurate oligodendroglioma grading.