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Uterine leiomyosarcoma metastatic to the thyroid.
Charles A Leath1, Warner K Huh, J Michael Straughn
1Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249-7333, USA. trey_leath@yahoo.com
Obstetrics and Gynecology
|November 9, 2002
Summary
This case study reports the first instance of uterine leiomyosarcoma spreading to the thyroid gland. The patient demonstrated remarkable survival with stable disease despite multiple metastatic episodes.
Area of Science:
- Gynecologic Oncology
- Oncology
- Pathology
Background:
- Uterine leiomyosarcoma is an aggressive malignancy.
- Distant metastasis is common, affecting organs like the lungs, liver, brain, and bone.
Observation:
- A woman in her fifth decade was diagnosed with stage IV uterine leiomyosarcoma.
- Initial diagnosis included chest metastasis confirmed via thoracotomy.
- The patient later developed metastatic disease to the thyroid gland.
Findings:
- This case is the first documented instance of uterine leiomyosarcoma metastasizing to the thyroid.
- The patient survived 71 months post-diagnosis of stage IV disease.
- Multiple episodes of asymptomatic, stable metastatic disease were observed despite various chemotherapeutic regimens.
Implications:
- Highlights the potential for rare metastatic sites in uterine leiomyosarcoma.
- Suggests the possibility of prolonged stable disease in advanced uterine leiomyosarcoma.
- Underscores the importance of considering unusual metastatic patterns in patient management.