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A flexible strategy for the divergent modification of pleuromutilin
Eric Bacqué1, François Pautrat, Samir Z Zard
1Aventis, Centre de Recherche de Romainville, 102 Route de Noisy, F-93235 Romainville, France.
Chemical Communications (Cambridge, England)
|November 15, 2002
Abstract:
The complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12.