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Extinction of operant behavior as the test for cognitive disorders induced with kainic acid
1Laboratory of Synaptic Transmission Mechanisms, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Puschino, Russia. arkhipov@iteb.serpukhov.su
Bulletin of Experimental Biology and Medicine
|November 26, 2002
Abstract:
Wistar rats were trained food-procuring task for 5 days and then extinction of the operant behavior was studied for 6 days after injection of an epileptogen (kainic acid, 8 mg/kg, intraperitoneally). Kainic acid induced long-term impairment of inhibitory processes in the brain, which impeded extinction of a conditioned response. This effect was prevented by daily injections of anticonvulsant sodium valproate (300 mg/kg for 4 days).