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Effect of detergent on powder triboelectrification
Matti Murtomaa1, Kalle Ojanen, Ensio Laine
1Department of Physics, University of Turku, FIN-20014, Turku, Finland. matti.murtomaa@utu.fi
Summary
Detergent residues on manufacturing equipment significantly alter pharmaceutical powder charging. This study reveals how surface contamination impacts triboelectrification, affecting powder properties and manufacturing processes.
Area of Science:
- Pharmaceutical Engineering
- Materials Science
- Surface Chemistry
Background:
- Triboelectrification of pharmaceutical powders is a critical issue impacting manufacturing processes.
- Powder adhesion and flow are significantly influenced by electrostatic charges generated during handling.
- Understanding triboelectrification is essential for ensuring product quality and process efficiency.
Purpose of the Study:
- To investigate the impact of detergent contamination on stainless steel surfaces on the triboelectrification of microcrystalline cellulose.
- To compare the charging behavior of pharmaceutical powders with polystyrene spheres under similar conditions.
- To establish a triboelectric series for detergents and powders relevant to pharmaceutical manufacturing.
Main Methods:
- Experimental study of microcrystalline cellulose (MCC) tribocharging against stainless steel pipes treated with various detergents.
- Comparative charging experiments using polystyrene spheres.
- Analysis of powder adhesion and its effect on triboelectrification.
- Determination of charge generation under controlled contamination levels.
Main Results:
- Detergent contamination on the stainless steel surface significantly affects the triboelectrification of microcrystalline cellulose.
- Powder adhesion plays a crucial role in the triboelectrification process.
- A discernible triboelectric series was established for the tested detergents and powders, with a single exception.
- Polystyrene spheres exhibited different charging behavior compared to MCC, highlighting material-specific interactions.
Conclusions:
- Detergent residues are a critical factor influencing electrostatic charging in pharmaceutical powder processing.
- Surface contamination control is essential to mitigate adverse effects on powder flow, dose uniformity, and manufacturing.
- The findings provide valuable insights for optimizing cleaning protocols and material selection in pharmaceutical manufacturing to prevent electrostatic issues.