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A study on the nickel II-famotidine complexes.
Malgorzata Barańska1, Elzbieta Gumienna-Kontecka, Henryk Kozlowski
1Faculty of Chemistry, Jagiellonian University, 3 Ingardena Str., 30-060 Cracow, Poland.
Journal of Inorganic Biochemistry
|December 3, 2002
Summary
Nickel(II) forms pH-dependent complexes with famotidine. Researchers characterized two distinct Ni(II)-famotidine complexes, one octahedral and one square-planar, detailing their structures and coordination chemistry.
Area of Science:
- Coordination Chemistry
- Inorganic Chemistry
- Analytical Chemistry
Background:
- Famotidine is a histamine H2 receptor antagonist.
- Nickel(II) is a transition metal ion with diverse coordination chemistry.
- Understanding metal-ligand interactions is crucial for various applications.
Purpose of the Study:
- To investigate the complexation of Nickel(II) with famotidine.
- To characterize the structure and properties of the formed Ni(II)-famotidine complexes.
- To elucidate the coordination modes and binding sites of famotidine in Ni(II) complexes.
Main Methods:
- Potentiometric studies to determine complex formation and stability.
- Spectroscopic techniques including FT-IR, Raman, and NMR (1H, 13C, 15N) for structural elucidation.
- Mass spectrometry for molecular weight determination.
- Ab initio HF/CEP-31G calculations for vibrational band assignment.
Main Results:
- Three pH-dependent Ni(II)-famotidine complexes were identified: [NiHL](3+), [NiL](2+), and [NiH(-2)L].
- Two complexes, [NiL](2+) (octahedral, paramagnetic) and [NiH(-2)L] (square-planar, diamagnetic), were isolated.
- The octahedral complex involves thiazole N(9) and guanidine N(3) nitrogens, coordinated with water and perchlorate anions.
- The square-planar complex features coordination through four famotidine nitrogen atoms (N(3), N(9), N(16), N(20)).
Conclusions:
- Famotidine acts as a multidentate ligand coordinating to Ni(II) through various nitrogen atoms.
- The geometry and magnetic properties of the Ni(II) complexes are pH-dependent.
- Spectroscopic and computational methods successfully confirmed the coordination sites and structural features of the complexes.