Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adverse effects of beta-agonists.

Malcolm R Sears1

  • 1Firestone Institute for Respiratory Health, St Joseph's Healthcare and Master University, Hamilton, Ontario, Canada.

The Journal of Allergy and Clinical Immunology
|December 5, 2002
PubMed
Summary

Short-acting beta-agonists can cause adverse effects like tachycardia and tremor, with potential risks for airway hyperresponsiveness. Long-acting beta-agonists appear safer regarding airway function and mortality.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protective effects of dog allergen and endotoxin for lung function and asthma.

The Journal of allergy and clinical immunology·2026
Same author

From Fetus to Eight: the CHILD Cohort Study.

American journal of epidemiology·2024
Same author

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization.

Cell host & microbe·2024
Same author

Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children.

Nature communications·2024
Same author

Divergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition.

Microbiome·2024
Same author

Maturational patterns of the infant gut mycobiome are associated with early-life body mass index.

Cell reports. Medicine·2023

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Genetics

Background:

  • Short-acting beta-adrenergic receptor agonists (SABAs) have predictable adverse effects like tachycardia and tremor.
  • These drugs can also impact serum potassium and glucose levels, with tolerance developing over time.
  • Comorbidity and hypoxemia can increase arrhythmia risk with SABA use.

Purpose of the Study:

  • To review the adverse effects of short-acting and long-acting beta-agonists.
  • To investigate the relationship between beta-agonists and asthma mortality.
  • To explore the impact of genetic variants and enantiomers on beta-agonist effects.

Main Methods:

  • Review of pharmacological effects and clinical outcomes.
  • Analysis of postmarketing surveillance data.
  • Consideration of genetic factors influencing drug response.

Main Results:

  • SABAs can cause dose-related adverse effects and increase airway hyperresponsiveness, potentially linked to asthma deaths.
  • Genetic variants in beta-adrenergic receptors influence susceptibility to SABA adverse effects.
  • Long-acting beta-agonists (LABAs) show similar but less pronounced effects and have not been linked to increased airway hyperresponsiveness in adults.

Conclusions:

  • Adverse effects of SABAs on airway function, not cardiotoxicity, may explain asthma mortality epidemics.
  • LABAs appear to have a better safety profile regarding airway hyperresponsiveness and mortality in adults.
  • Further research is needed on the impact of beta-agonist enantiomers.

Related Experiment Videos