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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
[Nijmegen breakage syndrome associated with pulmonary lymphoma]
D Moreno Pérez1, F J García Martín, R Vázquez López
1Unidades de Infectología e Inmunodeficiencias Pediátricas. Hospital Materno-Infantil. Complejo Hospitalario Carlos Haya. Málaga. España.
Abstract:
Nijmegen breakage syndrome is a rare autosomal recessive disorder characterized by a peculiar dysmorphic syndrome (microcephaly, "bird-like" facies, short stature), combined immunodeficiency with recurrent infections, X-ray hypersensitivity and predisposition to malignancy, mainly lymphomas, as a consequence of chromosome instability due to anomalies in the repair of double-stranded DNA breaks.We present a 6-year-old boy with Nijmegen breakage syndrome, who developed a large B-cell non-Hodgkin's lymphoma, localized in the lung without nodal involvement.
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