Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic syndrome burden, determinants and treatment status in an urban slum resettlement colony in Delhi, India.

International health·2024

Same author

Neutralizing antibody responses to SARS-CoV-2: A population based seroepidemiological analysis.

Indian journal of medical microbiology·2022

Same author

Telemedicine: Embracing virtual care during COVID-19 pandemic.

Journal of family medicine and primary care·2020

Same author

Magnitude of domestic violence and its socio-demographic correlates among pregnant women in Delhi.

Journal of family medicine and primary care·2019

Same author

Haemostasis and analgesia with autologous platelet-rich plasma in tonsillectomy.

The Journal of laryngology and otology·2019

Same author

Ichthyosis Hystrix.

Indian journal of dermatology and venereology·2017

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Wheat gluten as a pathogenic factor in schizophrenia.

M M Singh, S R Kay

Science (New York, N.Y.)

|January 30, 1976

Summary

Wheat gluten challenge worsened schizophrenia symptoms in patients on a restricted diet. Symptoms improved after gluten withdrawal, suggesting gluten promotes schizophrenia progression.

Area of Science:

Psychiatry
Neuroscience
Dietary Science

Background:

Schizophrenia is a complex mental disorder.
Dietary interventions are explored for managing schizophrenia.
Optimal neuroleptic treatment is standard care.

Purpose of the Study:

To investigate the effect of wheat gluten challenge on schizophrenia patients.
To determine if wheat gluten exacerbates schizophrenia symptoms during optimal treatment.

Main Methods:

Patients with schizophrenia were on a cereal grain-free and milk-free diet.
A "blind" wheat gluten challenge was administered.
Neuroleptic doses were kept optimal and constant.

Main Results:

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Jul 5, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Therapeutic progress in schizophrenia patients was interrupted or reversed during gluten challenge.
Exacerbation was independent of neuroleptic dose variations.
Improvement resumed after the gluten challenge was terminated.

Conclusions:

Wheat gluten appears to have a primary schizophrenia-promoting effect.
Dietary factors like wheat gluten may significantly impact schizophrenia.
Further research into gluten's role in schizophrenia is warranted.