Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Na+ signals at central synapses.

C R Rose1

  • 1Physiological Institute, University of Munich, Germany. rose@lrz.uni-muenchen.de

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|December 7, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CrossTalk opposing view: NKCC1 in the luminal membrane of choroid plexus is outwardly directed under basal conditions and contributes directly to cerebrospinal fluid secretion.

The Journal of physiology·2020
Same author

Astrocyte sodium signaling and neuro-metabolic coupling in the brain.

Neuroscience·2015
Same author

High-resolution Na+ imaging in dendrites and spines.

Pflugers Archiv : European journal of physiology·2003
Same author

Stores not just for storage. intracellular calcium release and synaptic plasticity.

Neuron·2001
Same author

Exciting glial oscillations.

Nature neuroscience·2001
Same author

NMDA receptor-mediated Na+ signals in spines and dendrites.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
Same journal

Nonclustered Protocadherins in Autism: Integrating Cell Adhesion and Activity-Dependent Signalling.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Brain-on-a-Chip and Blood-Brain Barrier-on-a-Chip Modeling for Neurodegenerative Disorders: Recent Progress.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

The Left Ventral Premotor Cortex: Powerful Roles in Reading.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

The 3-Body Problem: How Astrocytes May Govern Plasticity.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Heat Shock Proteins in Schizophrenia: Integrating Stress Responses, Molecular Pathways, and Emerging Therapeutic Strategies.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
See all related articles

Animal cells maintain a sodium ion gradient crucial for neuron function. Recent studies reveal significant intracellular sodium transients during neural activity, impacting synaptic plasticity and transmission.

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Ion Transport

Background:

  • Animal cells, particularly vertebrate neurons, rely on a steep inward electrochemical gradient for sodium ions (Na+).
  • This Na+ gradient is essential for regulating intracellular ions and driving electrical events like action potentials and postsynaptic currents.
  • Previous research hinted at a role for Na+ in activity-dependent synaptic plasticity.

Purpose of the Study:

  • To review recent findings on intracellular Na+ transients during neuronal activity.
  • To highlight the significance of these Na+ transients in postsynaptic dendrites and dendritic spines.
  • To discuss the potential influence of Na+ transients on synaptic transmission and plasticity.

Main Methods:

  • Review of recent scientific literature focusing on intracellular Na+ dynamics.

Related Experiment Videos

  • Analysis of studies measuring Na+ transients in response to action potential firing and synaptic transmission.
  • Examination of experimental data demonstrating the amplitude and location of Na+ transients.

    • Main Results:

    • Substantial intracellular Na+ transients occur in postsynaptic dendrites and dendritic spines during neuronal activity.
    • These activity-induced Na+ transients exhibit large amplitudes.
    • The presence of these transients suggests a significant impact on the electrical and biochemical properties of dendritic structures.

    Conclusions:

    • Activity-induced intracellular Na+ transients are a significant feature of neuronal function.
    • These Na+ transients likely play a critical role in modulating synaptic transmission and plasticity.
    • Further research is warranted to fully elucidate the mechanisms and consequences of these Na+ signals.