Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

831
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
831
Biosynthesis in Bacteria01:24

Biosynthesis in Bacteria

481
Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
481
Synthetic Biology02:55

Synthetic Biology

5.4K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.4K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

3.0K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
3.0K
ATP and Macromolecule Synthesis01:28

ATP and Macromolecule Synthesis

6.8K
Biological macromolecules are organic compounds, predominantly composed of carbon atoms. The carbon atoms are covalently bonded with hydrogen, oxygen, nitrogen, and other minor elements. There are four major biological macromolecule classes: carbohydrates, lipids, proteins, and nucleic acids.
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
6.8K
SN2 Reaction: Mechanism02:27

SN2 Reaction: Mechanism

16.9K
The kinetic studies of SN2 reactions suggest an essential feature of its mechanism: it is a single-step process without intermediates. Here, both the nucleophile and the substrate participate in the rate-determining step.
The presence of the more electronegative halogen in the substrate creates a polarized carbon-halide bond. The halide pulls the electron cloud generating an electrophilic center at the carbon atom. Thus, the carbon atom carries a partial positive charge while the halide has a...
16.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A career with a natural interest in total synthesis.

Nature reviews. Chemistry·2025
Same author

Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II.

The Journal of organic chemistry·2025
Same author

Straightforward, scalable, solution-phase synthesis of peptide bonds in flow.

Journal of flow chemistry·2025
Same author

Antascomicin B stabilizes FKBP51-Akt1 complexes as a molecular glue.

Bioorganic & medicinal chemistry letters·2024
Same author

Continuous flow synthesis enabling reaction discovery.

Chemical science·2024
Same author

Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides.

The Journal of organic chemistry·2024
Same journal

Creating a Masterpiece. The Road to (and Beyond) Woodward and Hoffmann's 1969 Angewandte Chemie Treatise.

Chemical record (New York, N.Y.)·2026
Same journal

Advancements in the Synthesis of Heterocyclic N-Oxide via Inter- and Intramolecular Cyclization Reactions.

Chemical record (New York, N.Y.)·2026
Same journal

Solid State Supercapacitors for Energy Storage: Materials, Device Engineering, Multifunctionality, and Emerging Electrical Applications.

Chemical record (New York, N.Y.)·2026
Same journal

Chiral Graphene Quantum Dots and Carbon Dots: From Chirality Induction to Spin-Selective Effects and Advanced Applications.

Chemical record (New York, N.Y.)·2026
Same journal

Engineering the Electrospun Separators for Next-Generation Lithium-Based Batteries.

Chemical record (New York, N.Y.)·2026
Same journal

Catalyst-Free Aerobic Photooxidation: Mechanistic Pathways and Sustainability Perspectives.

Chemical record (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Dec 29, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

7.2K

Organic synthesis in a changing world.

Steven V Ley1, Ian R Baxendale

  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. svl1000@cam.ac.uk

Chemical Record (New York, N.Y.)
|December 7, 2002
PubMed
Summary
This summary is machine-generated.

Professor Ley

More Related Videos

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

7.2K
Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
06:52

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile

Published on: October 30, 2018

37.2K

Related Experiment Videos

Last Updated: Dec 29, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
09:56

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis

Published on: September 6, 2019

7.2K
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

7.2K
Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
06:52

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile

Published on: October 30, 2018

37.2K

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry

Background:

  • Professor Steven V. Ley's research group focuses on advancements in organic synthesis.
  • The field of organic synthesis is continually evolving.

Purpose of the Study:

  • To provide a comprehensive overview of solid-supported reagents and scavengers.
  • To highlight their application in modern organic synthesis.

Main Methods:

  • Development of solid-supported reagents.
  • Application of solid-supported scavengers.
  • Utilizing these tools in organic synthesis.

Main Results:

  • Demonstration of efficient and effective solid-supported reagents.
  • Showcasing the utility of scavengers for purification.
  • Advancements in synthetic methodologies.

Conclusions:

  • Solid-supported reagents and scavengers offer significant advantages in organic synthesis.
  • These methods contribute to greener and more efficient chemical processes.
  • Ongoing research continues to expand their applications.