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Brain control of the lower urinary tract
1Department of Urology, Academic Medical Center, University of Amsterdam, The Netherlands.
Scandinavian Journal of Urology and Nephrology. Supplementum
|December 12, 2002
Summary
This review details the neural control of bladder function, outlining key pathways for micturition and continence. Understanding these neural circuits is crucial for diagnosing and treating urological dysfunction.
Area of Science:
- Neuroscience
- Urology
Background:
- Recent advancements have significantly expanded our understanding of the neural pathways governing micturition and continence.
- The mammalian nervous system comprises complex neural circuits essential for regulating bladder function.
Purpose of the Study:
- To review and synthesize findings from animal and human studies on the neural control of micturition and continence.
- To discuss the pathophysiology of urological dysfunctions related to these neural pathways.
Main Methods:
- Comprehensive literature review of animal and human experimental data.
- Analysis of the roles of specific neural components in bladder control.
Main Results:
- Identified four critical neural system components: bladder/autonomic ganglion cells, spinal cord motoneurons/interneurons, caudal brainstem, and cortical/subcortical areas.
- These components form the basis of the micturition reflex, interconnected via peripheral nerves and central tracts.
- Neural pathway lesions can lead to hypoactivity, hyperactivity, or loss of control in micturition and continence.
Conclusions:
- The neural control of micturition and continence involves a complex interplay of peripheral and central nervous system components.
- Dysfunction in these neural pathways underlies various urological disorders, impacting bladder function and urine control.