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Drug-induced nail abnormalities.

Bianca Maria Piraccini1, Matilde Iorizzo, Antonella Tosti

  • 1Department of Dermatology, University of Bologna, Bologna, Italy. bmpiracc@med.unibo.it

American Journal of Clinical Dermatology
|December 13, 2002
PubMed
Summary
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This review details drug-induced nail abnormalities, such as Beau

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Drug administration can lead to various nail abnormalities.
  • These changes can affect the nail matrix, nail bed, or surrounding tissues.
  • Commonly observed symptoms include Beau's lines, melanonychia, onycholysis, and pyogenic granulomas.

Purpose of the Study:

  • To review and summarize drug-induced nail symptoms.
  • To identify common nail abnormalities and associated medications.
  • To include radiotherapy-induced nail effects in the review.

Main Methods:

  • Literature review of drug-induced nail abnormalities.
  • Analysis of common nail symptoms and their causes.
  • Inclusion of radiotherapy-induced nail effects.

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Main Results:

  • Drug-induced nail changes are often asymptomatic and affect multiple nails.
  • Key symptoms include Beau's lines/onychomadesis, melanonychia, onycholysis, and periungual pyogenic granulomas.
  • Retinoids, indinavir, and chemotherapy agents are frequent culprits; radiotherapy also causes nail effects.

Conclusions:

  • Understanding drug-induced nail symptoms is crucial for clinical practice.
  • Early identification can help manage adverse effects and patient care.
  • Nail changes serve as potential indicators of systemic drug toxicity.