Related Experiment Videos
Formulation of electrically conducting microemulsion-based organogels.
Shilpa Kantaria1, Gareth D Rees, M Jayne Lawrence
1Department of Pharmacy, King's College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK.
International Journal of Pharmaceutics
|December 14, 2002
Summary
Researchers developed gelatin-based organogels using microemulsions. Isopropyl myristate and Aerosol-OT were key components for forming these novel drug delivery systems.
Area of Science:
- Materials Science
- Physical Chemistry
- Pharmaceutical Sciences
Background:
- Microemulsion-based organogels (MBGs) offer potential for drug delivery.
- Understanding factors influencing microemulsion and MBG formation is crucial for formulation development.
Purpose of the Study:
- To prepare gelatin-containing, electrically conducting, rigid water-in-oil (w/o) microemulsion-based organogels (MBGs).
- To investigate the role of oils and surfactants in forming stable w/o microemulsions and subsequent MBGs, with and without a model drug.
Main Methods:
- Formulation of w/o microemulsions using various oils (e.g., isopropyl myristate) and surfactants (e.g., Aerosol-OT, non-ionic surfactants).
- Incorporation of gelatin into microemulsions to form MBGs.
- Evaluation of formulation components and conditions affecting microemulsion and MBG stability and formation.
Main Results:
- Isopropyl myristate (IPM) was identified as a suitable oil for supporting w/o microemulsion formation.
- Aerosol-OT (AOT) was the most effective surfactant, with synergistic effects observed when combined with non-ionic surfactants.
- Gelatin-containing MBGs were successfully formed using AOT and specific oil/surfactant combinations, including in the presence of sodium salicylate, but not with non-ionic surfactants alone.
Conclusions:
- The study successfully prepared novel gelatin-containing MBGs with potential pharmaceutical applications.
- AOT, in combination with IPM and certain non-ionic surfactants, is critical for forming stable w/o microemulsions and subsequent MBGs.
- Formulation composition significantly impacts the ability to form percolated microstructures necessary for supramolecular gelatin assembly and MBG formation.