Histocompatibility of photocrosslinked polyanhydrides: a novel in situ forming orthopaedic biomaterial

Cell-polymer interactions in subcutaneous and bony tissue were examined for a novel class of in situ forming and surface eroding polyanhydride networks. Specifically, photopolymerized disks of several polyanhydride compositions were implanted subcutaneously in rats, and the tissue was analyzed for an inflammatory response. The compositions elicited varied histological responses, ranging from highly active cell layers to moderate fibrous capsules, depending on the degrading polymer composition. Furthermore, one composition was photopolymerized in a model orthopaedic defect in the proximal tibia. The feasibility of photopolymerizing the methacrylated monomers in situ and the adherence of the photocrosslinked polyanhydride to the medullary canal were examined.