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Visual and ocular changes associated with exposure to two tertiary amines.

E H Page1, C K Cook, M A Hater

  • 1Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R-10, Cincinnati, Ohio 45226-1998, USA.

Occupational and Environmental Medicine
|December 25, 2002
PubMed
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Exposure to tertiary amines like DMIPA and DMAE in label printing plants is linked to visual disturbances and ocular changes. Workers experienced blurry vision, halo vision, and corneal opacity with increased amine exposure.

Area of Science:

  • Occupational Health
  • Ophthalmology
  • Industrial Hygiene

Background:

  • Label printing plants utilize chemicals such as dimethylisopropanolamine (DMIPA) and dimethylaminoethanol (DMAE).
  • Potential health effects of occupational chemical exposure, particularly on vision, require thorough investigation.

Purpose of the Study:

  • To investigate the association between exposure to DMIPA and DMAE in a label printing environment and the occurrence of visual disturbances and ocular changes.
  • To quantify the relationship between specific amine concentrations and reported symptoms or observed ocular conditions.

Main Methods:

  • A two-week study involving questionnaires for visual symptoms, comprehensive eye examinations (visual acuity, contrast sensitivity, slit lamp biomicroscopy, pachymetry), and industrial hygiene monitoring.

Related Experiment Videos

  • Personal breathing zone (PBZ) air samples were collected to measure time-weighted average (TWA) concentrations of DMIPA and DMAE.
  • Statistical analysis was performed to correlate amine exposure levels with reported visual disturbances and ocular findings.

    • Main Results:

    • A significantly higher prevalence of blurry vision was reported by line workers compared to prime workers, correlating with higher TWA concentrations of DMIPA and total amines.
    • Increased exposure to total amines was associated with a higher risk of reporting blurry vision, halo vision, blue-grey vision, and the development of corneal opacity.
    • A statistically significant relationship was found between total amine concentration and reduced bilateral visual acuity and contrast sensitivity at 2.5% contrast.

    Conclusions:

    • Occupational exposure to tertiary amines in the label printing industry is associated with adverse visual effects, including blurry vision, halo vision, and blue-grey vision.
    • Exposure to these amines can lead to ocular changes such as corneal opacity and measurable decrements in visual acuity and contrast sensitivity.
    • The findings underscore the importance of monitoring and controlling airborne amine concentrations in industrial settings to protect worker vision.