A study of extra genital effects of estrogen and progesterone

Although some extragenital effects (EGEs) of the female sex steroids (FSS) have been known for fairly long time, serious research on it has been taken up only in recent time. This paper has tried to explore the EGEs of Estrogen (E) and Progesterone (P). This study was based on human beings as experimental subjects. In this clinical study, three further subdivisions were made: (i) Patients of dysfunctional uterine bleeding (DUB) who were therapeutically advised to use orally ingestible synthetic P tablets. These subjects were studied for any P induced changes in the psychoanalytical score, EEG, lung function tests (LUFTs), ECG; their blood Female sex steroid levels were also measured. (ii) Another group of women suffering from perimenopausal syndrome were given synthetic E tablets and the E induced changes (if any) of the same above mentioned parameters were studied. (iii) A third group consisting of healthy women were given oral contraceptive pills (OCP) containing both E and P and the above mentioned parameters were studied to see whether the OCP could cause any change. The results have been discussed. Attempts have been made to see whether our findings give any hint of any mode of action of the FSS studied and so forth.