[Study on the molecular structure and function of protein kinase C isoenzyme]

Protein kinase C (PKC) is a serine/threonine kinase family consisting at least 11 related isoenzymes, and it can be divided into four distinct classes, conventional PKC (cPKCs), novel or new PKC (nPKCs), atypical PKC (aPKCs), and PKC-u. All PKC members contain conserved and variant amino acid sequences in ATP binding sites, phosporyl transfer region, pseudosubstrate region, and phorbol ester binding sites. PKC isoenzymes exhibit distinct tissue distribution and play a critical role in cellular events. This review mainly summarized the PKC effects on tumorigenesis, tumor invasion and metastasis, tumor multidrug resistance, differentiation and development of hematopoietic progenitor cells, and hormonal production and secretion.