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In Situ Hybridization Techniques for Paraffin-Embedded Adult Coral Samples
Published on: August 31, 2018
Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra
Jyh-Horng Sheu1, Atallah F Ahmed, Ru-Ting Shiue
1Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China. sheu@mail.nsysu.edu.tw
Abstract:
Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.

