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Monomeric sarcoplasmic reticulum Ca(2+)-ATPase is functionally active
Kazuo Takeda1, Masaru Kawamura
1Department of Biology, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Journal of UOEH
|January 1, 2003
Abstract:
cRNAs for wild type and a functionless mutant of sarcoplasmic reticulum (SR) Ca(2+)-ATPase were co-injected into Xenopus oocytes in various molar ratios. SR Ca(2+)-ATPase activity of the microsomal fraction prepared from the injected oocytes increased linearly with increasing amounts of wild type cRNA. This result suggests that monomers are functional units of membrane-bound SR Ca(2+)-ATPase.