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Novel benzoylurea derivatives as potential antitumor agents; synthesis, activities and structure-activity
Ki-Jun Hwang1, Kyung-Ho Park, Chong-Ock Lee
1Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University, Dukjindong 664-14 Chonju 561-756, Korea. kijun@moak.chonbuk.ac.kr
Archives of Pharmacal Research
|January 4, 2003
Abstract:
A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50-100 times greater antitumor activities than the commercial product, Cisplatin.