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Epithelial-induced intrapulpal denticles in B6C3F1 mice
Philip H Long1, Ronald A Herbert
1Pathology Associates, A Charles River Company, West Chester, Ohio 45069, USA. plong@criver.com
Toxicologic Pathology
|January 7, 2003
Summary
Intrapulpal denticles, calcified structures in mouse incisors, were identified. These denticles can disrupt normal tooth development, leading to dental dysplasia and fractures.
Area of Science:
- Dental Histology
- Mouse Models
- Toxicology
Background:
- Intrapulpal denticles are calcified structures found within the pulp chamber of teeth.
- Their formation and impact on tooth development are not fully understood.
Purpose of the Study:
- To investigate the occurrence and histological characteristics of intrapulpal denticles in B6C3F1 mice.
- To determine the potential effects of intrapulpal denticles on tooth development and integrity.
Main Methods:
- Histological examination of maxillary incisors from control and treated B6C3F1 mice.
- Observation of denticle origin, structure, and progression during incisor growth.
Main Results:
- Multiple intrapulpal denticles were observed in maxillary incisors of both control and treated mice.
- Denticles originated from epithelial sheath projections and exhibited tubular dentin.
- Advanced denticles caused defects in dentinogenesis, altered tooth shape, microfractures, and incorporation into dentin.
Conclusions:
- Intrapulpal denticle formation is a previously unidentified alteration in mouse incisors.
- These denticles interfere with normal tooth development, potentially causing dental dysplasia and increasing susceptibility to malformation and fracture.