Related Experiment Video

Updated: Sep 27, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

[Etiological study on human rotavirus infections in children with acute gastroenteritis]

J Zhao1, H Cheng, L Yan

  • 1Capital Institute of Pediatrics, Beijing 100020, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|January 16, 2003
PubMed

Insights

Human rotavirus infections are a major cause of acute gastroenteritis in Chinese children. This study identified rotavirus RNA in 40.9% of samples, predominantly Group A, with varied genotypes and patterns.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Context:

  • Acute gastroenteritis is a significant health concern in infants and young children globally.
  • Rotavirus is a leading cause of severe diarrheal disease in this population.
  • Understanding the specific viral etiology in different geographical regions is crucial for public health interventions.

Purpose:

  • To investigate the prevalence and characteristics of human rotavirus (HRV) infections in children with acute gastroenteritis in China.
  • To identify the specific rotavirus groups, RNA patterns, and genotypes circulating in the studied population.

Summary:

  • Human rotavirus RNA was detected in 40.9% of 1968 fecal samples from children with acute gastroenteritis across 19 Chinese provinces.
  • The majority (99.6%) of detected rotaviruses belonged to Group A, with both long and short genomic patterns identified.
  • Four distinct HRV genotypes (4232, 4222, 3232, 3222) were identified, with variations observed across different years, seasons, patient ages, and regions.

Impact:

  • This research highlights rotavirus as a primary etiological agent of diarrhea in young Chinese children.
  • The findings provide valuable epidemiological data on rotavirus strains circulating in China, informing vaccine strategies and clinical management.
  • Understanding the diversity of rotavirus genotypes and patterns is essential for developing effective control measures and improving child health outcomes.
Abstract

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...