Related Experiment Video
Updated: Sep 27, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
[The relationship between expression of oncogene proteins and HBeAg in chronic hepatitis B virus infection]
Abstract:
To study the relationship between abnormal expression of oncogene protein and HBV replication, we detected the expression of protein products C-erbB-2 P185, ras P21 and tumorsuppressor gene product P53 and HBeAg in the serum of 64 patients with chronic HBV infection by using immunohistochemical technique and ELISA. The results were as follows. The positive detection rates of serum HBeAg in C-erbB-2 P185 and ras P21 oncogenes positive groups were 89.4% and 84.6% respectively, but only 20% and 48% in C-erbB-2 P185 and ras P21 negative groups. It suggested that there is a close correlation between the over-expression of C-erbB-2 P185, ras P21 and replication of HBV.
Related Concept Videos
Hepatitis
Cell Specific Gene Expression
Viral Hepatitis I: Introduction
Mechanisms of Retrovirus-induced Cancers
Jaundice
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

