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Brain microhemorrhages detected on T2*-weighted gradient-echo MR images
Yoshito Tsushima1, Jun Aoki, Keigo Endo
1Department of Radiology, Motojima General Hospital, Ohta, Gunma, Japan.
AJNR. American Journal of Neuroradiology
|January 21, 2003
Summary
Brain microhemorrhages are linked to hypertension and stroke history. Their presence may indicate small-vessel disease and predict future hemorrhagic stroke risk.
Area of Science:
- Neuroimaging
- Neurology
- Vascular Medicine
Background:
- Multifocal microhemorrhages are common in patients with systemic hypertension and spontaneous brain hemorrhage.
- T2*-weighted gradient-echo MRI is used to detect these lesions.
Purpose of the Study:
- To identify factors associated with microhemorrhages.
- To determine if microhemorrhages indicate different microangiopathies.
- To predict the risk of symptomatic hemorrhage.
Main Methods:
- Analysis of 2019 brain MRI studies from 2164 patients over 3 years.
- Exclusion of hemorrhages from vascular malformations, neoplasms, trauma, or surgery.
- Correlation analysis of microhemorrhage presence with clinical factors.
Main Results:
- Overall microhemorrhage incidence was 9.8%, most frequent in the lentiform nucleus, thalamus, and cortical-subcortical regions.
- Significant correlations found with history of hemorrhagic stroke, age, hypertension, and white matter hyperintensity.
- Cortical-subcortical microhemorrhages were more common in patients with prior lobar hemorrhagic stroke.
Conclusions:
- Microhemorrhages can be a marker for bleeding-prone small-vessel diseases.
- These lesions may indicate diverse microangiopathies.
- The presence of microhemorrhages predicts a higher risk of future hemorrhagic stroke.