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[Evaluation of 99mTc(V)-DMSA imaging in patients with pharyngolaryngeal carcinoma]
1Department of Nuclear Medicine, Union Hospital, Tongji Medical University, Wuhan 430022.
Objective:
To evaluate the value of tumor-seeking agent 99mTc(V)-DMSA in patients with pharyngolaryngeal carcinoma and its biodistribution in human being.
Method:
Planar and SPECT scintigraphy with 99mTc(V)-DMSA were performed in 12 patients with histologically confirmed pharyngolaryngeal carcinoma. The dynamic distribution in patients was also analyzed.
Result:
9 cases (11 lesions) showed increased uptake by planar imaging and 11 cases (19 lesions) were clearly demonstrated by SPECT images. Furthermore, distant metastatic lesions were showed in 5 patients. Biodistribution in patients showed the accumulation of 99mTc(V)-DMSA in kidney was significantly greater than other organs.
Conclusion:
These results could suggested the clinical utility of 99mTc(V)-DMSA, specially with SPECT, for detecting primary pharyngolaryngealcarcinoma and their metastatic lesions (both local and distant). 99mTc(V)-DMSA Tumor-seeking agent Pharyngolaryngeal carcinoma.
