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Published on: February 28, 2019
[The determination of p53 protein in maxillary sinus carcinoma and its prognosis value]
1Department of Otolaryngology, General Hospital of Shenyang Military Region, Shenyang 110015.
Objective:
To determine whether p53 protein overexpression correlated with early tumor recurrence in carcinoma of maxillary sinus.
Method:
Forty-five patients with T2N0M0 squamous cell carcinoma of maxillary sinus were treated with operation and/or radiotherapy. The median follow up time was 3 years. The ratio of local control was 62.2% (28 patients), as control group; The ratio of local recurrence and/or metastasis was 37.8% (17 patients), as experiment group. Cancer specimens were obtained before treatment. p53 protein overexpression, which indicated a mutated p53 gene, was analyzed by immunohistochemistry, using the mouse monoclonal antibody DO-7.
Result:
Approximately 88.2% of the carcinoma that recurred locally overexpressed p53 protein, compared with only 28.6% of those with local control (P < 0.01). No significant relation was noted between p53 protein overexpression and pathohistologic grade. Intensity of staining did not predict tumor recurrence.
Conclusion:
The study demonstrated that the p53 protein is an important prognostic marker on gene level for maxillary sinus carcinoma.
