[Role of epithelial cell proliferation and apoptosis in human middle ear cholesteatoma]
Related Experiment Video
Updated: Sep 27, 2026

Endoscopic Cholesteatoma Surgery
Published on: January 19, 2022
1Department of Otolaryngology Head and Neck Surgery, First Clinical College of Jiling University, Changchun 130021.
Objective:
To determine the role of middle ear epithelial cell proliferation and apoptosis in the pathogenesis of human cholesteatoma.
Method:
33 cholesteatoma, 25 auditory meatal skin of cholesteatoma and 10 normal human auditory meatal skin were detected by using immunohistochemistry analysis for cell proliferation with Ki 67, PCNA and PCNA antibody and TUNTEL methods for cell apoptosis.
Result:
PCNA expression and apoptosis cells exists different quantity in cholesteatoma, auditory metal skin of cholesteatoma and normal human auditory meatal skin and distributes in various cell layer. There were positive correlation between p53 and PCNA as well as negative correlation between p53 and apoptosis.
Conclusion:
The dyregulation of proliferation and apoptosis in keratinocyte is important in pathogenesis of cholesteatoma.
Related Concept Videos
Renewal of Skin Epidermal Stem Cells
Cellular Adaptation III: Hyperplasia
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Apoptosis
Growth of Cartilage and Bone Tissue
Cellular Adaptation IV: Dysplasia and Metaplasia

