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Updated: Sep 27, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
[Central nervous system calcium homeostasis imbalance and brain aging]
1Institute of Materia Medica, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College (PUMC), Beijing 100050.
Abstract:
Brain aging is associated with a marked decline of memory. The calcium homeostasis imbalance hypothesis postulated that sustained changes in the regulation of intracellular Ca2+ concentration, [Ca2+]i are the major cause of brain aging. Aging may cause the increase of the [Ca2+]i through many mechanisms. These alterations would in turn affect the synaptic transduction, neurotransmitter release and signal transduction, cause memory deficit. This article reviewed the progress about this hypothesis in recent years.
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