[Central nervous system calcium homeostasis imbalance and brain aging]

Brain aging is associated with a marked decline of memory. The calcium homeostasis imbalance hypothesis postulated that sustained changes in the regulation of intracellular Ca2+ concentration, [Ca2+]i are the major cause of brain aging. Aging may cause the increase of the [Ca2+]i through many mechanisms. These alterations would in turn affect the synaptic transduction, neurotransmitter release and signal transduction, cause memory deficit. This article reviewed the progress about this hypothesis in recent years.