Related Experiment Video
Updated: Sep 27, 2026

Studying the Coding Profiles of Somatic Stimulation on Cardiac-locked Neuronal Responses in the Rat Spinal Dorsal Horn
Published on: May 23, 2025
[Analgesic mechanisms of noradrenaline in the spinal dorsal horn]
1Department of Anatomy, K. K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032.
Abstract:
The superficial laminae of the spinal dorsal horn play important roles in nociceptive transmission and modulation. Noradrenergic fibers originated from brainstem pain-control system terminate and release noradrenaline (NA) in the superficial dorsal horn. The released NA might take part in the modulation of nociceptive transmission through the following pathways: (1) inhibits the glutamate and substance P release from primary afferent terminals; (2) increases the release of inhibitory neurotransmitters from lamina II (substantia gelatinosa) neurons. Morphological findings also raise the possibility that NA directly inhibits projection neurons in laminae I/III which convey the nociceptive information to the thalamus, thus inhibit nociceptive transmission at spinal level.
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