Related Experiment Video
Updated: Sep 27, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
[Advancement in mechanisms of long-term potentiation]
1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050.
Abstract:
Synaptic plasticity in mammalian brain is one of the most widely studied topics in neuroscience over the last decade. Long-term potentiation (LTP), mainly involving post-synaptic mechanisms, is a reflection of neural plasticity. Study on the mechanisms of LTP was formerly focused on the properties of NMDA receptor and the intracellular cascade of reaction after activation of the receptor. However, the definition of "silent synapses" with only NMDA receptors without AMPA receptors was frequently referred in LTP study, showing the importance of AMPA receptor in post-synaptic mechanism of LTP.
Related Concept Videos
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Postsynaptic Potential (PSP)
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...

