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[Molecular candidates for capacitative calcium entry channel]
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|January 28, 2003
Summary
Store depletion signals open calcium channels via mechanisms like diffusible messages or protein interactions. This review explores TRP homologues and capacitative calcium entry.
Area of Science:
- Cellular biology
- Molecular physiology
- Ion channel function
Context:
- Intracellular calcium stores regulate cellular processes.
- Store depletion triggers calcium influx via store-operated calcium channels (SOCs).
- Capacitative calcium entry (CCE) or calcium release-activated calcium channels (CRAC) are crucial for calcium homeostasis.
Purpose:
- To review recent studies on TRP homologues involved in CCE.
- To explore proposed mechanisms coupling store depletion to SOC opening.
- To discuss the electrophysiological phenotypes associated with CCE.
Summary:
- Calcium influx through SOCs is initiated by the depletion of intracellular calcium stores.
- Drosophila TRP and TRPL proteins are identified as cation channels potentially mediating CCE.
- The precise mechanism linking store depletion to SOC activation remains under investigation, with proposed models including diffusible signals, protein interactions, or vesicle secretion.
Impact:
- Understanding CCE mechanisms is vital for numerous physiological processes.
- TRP channels are implicated in various cellular functions and diseases.
- This review highlights current research directions and knowledge gaps in CCE.