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Updated: Aug 4, 2026

Isolation of Soluble and Insoluble PrP Oligomers in the Normal Human Brain
Published on: October 3, 2012
An evolutionary basis for scrapie disease: identification of a fish prion mRNA
Eric Rivera-Milla1, Claudia A O Stuermer, Edward Málaga-Trillo
1Department of Biology, University of Konstanz, 78457, Konstanz, Germany.
Abstract:
Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.
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