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In vivo molecular imaging
1Department of Biochemistry & Molecular Biophysics, Arizona Cancer Center, University of Arizona Health Sciences Center, Tucson 85724-5024, USA. gillies@email.arizona.edu
Journal of Cellular Biochemistry. Supplement
|January 29, 2003
Summary
Molecular imaging visualizes molecular phenotypes using various systems and probes. Advancements require interdisciplinary collaboration, particularly from molecular and cellular biochemists.
Area of Science:
- Biomedical imaging
- Molecular biology
Background:
- Molecular imaging visualizes molecular phenotypes in vivo.
- It utilizes modalities like nuclear magnetic resonance, ultrasound, and optical imaging.
- Contrast is generated using exogenous probes or transgenes.
Purpose of the Study:
- To provide an overview of the field of molecular imaging.
- To highlight current and emerging technologies.
- To emphasize the need for interdisciplinary collaboration.
Main Methods:
- Utilizes imaging systems (radionuclides, NMR, ultrasound, optical spectrum).
- Employs exogenous probes (e.g., glucose analogs, receptor-targeted agents) and transgenes (reporter proteins, enzymes).
- Incorporates in vivo assays for protein-protein interactions and mRNA expression.
Main Results:
- Demonstrates diverse strategies for molecular contrast generation.
- Highlights advanced techniques like in vivo interaction and expression assays.
- Underscores the complexity and potential of designing novel imaging agents.
Conclusions:
- Molecular imaging is a rapidly evolving field with significant potential.
- Advancements depend on the design of new imaging agents.
- Requires substantial input from molecular and cellular biochemists.
