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Related Experiment Videos

Role of elastin polymorphisms in panic disorder.

Robert A Philibert1, Jeffrey J Nelson, Bruce Bedell

  • 1Department of Psychiatry, The University of Iowa, Rm 2-205 Psychiatry Research/MEB, Iowa City, Iowa, USA. robert-philibert@uiowa.edu

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|January 30, 2003
PubMed
Summary
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Genetic analysis of the elastin gene (ELN) in panic disorder (PD) families did not reveal a significant link. While some ELN gene variations were found, they do not appear to be a major factor in the genetic predisposition to panic disorder.

Area of Science:

  • Neuroscience
  • Genetics
  • Cardiology

Background:

  • Panic disorder (PD) is a neuropsychiatric condition often comorbid with mitral valve prolapse.
  • Elastin, a key protein in heart valves, is encoded by the elastin gene (ELN).
  • Previous genome screens suggested a potential linkage between PD and the chromosomal region containing ELN.

Purpose of the Study:

  • To investigate the role of elastin gene (ELN) exonic polymorphisms in the genetic susceptibility to panic disorder (PD).
  • To analyze the minimal essential promoter and coding regions of ELN in individuals with PD.

Main Methods:

  • Single-strand conformational polymorphism (SSCP) analysis was used to screen ELN regions.
  • Case-control analysis and linkage analysis in multiplex pedigrees were performed.

Related Experiment Videos

  • Genetic variations in ELN were examined in 23 independent probands and their families.

    • Main Results:

    • Three polymorphisms in the ELN gene were identified, including one resulting in a non-conservative amino acid substitution.
    • No significant association was found between ELN polymorphisms and panic disorder in case-control analyses.
    • Linkage analysis in multiplex pedigrees did not support a role for exonic ELN polymorphisms in PD.

    Conclusions:

    • Exonic polymorphisms in the elastin gene (ELN) are unlikely to be a major contributor to the genetic vulnerability for panic disorder (PD).
    • Further research may be needed to explore other genetic or environmental factors influencing PD development.