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Lignocaine gel: does it cause urethral pain rather than prevent it?
Kuo J Ho1, Trevor J Thompson, Aidan O'Brien
1Department of Urology, Craigavon Area Hospital Group Trust, 68 Lurgan Road, Portadown, County Armagh BT63 5QQ, Northern Ireland, UK.
European Urology
|February 5, 2003
Summary
Plain aqueous gel significantly reduces urethral discomfort compared to lignocaine gel during instillation. This finding suggests the chemical content of lignocaine gel contributes to pain during urethral procedures.
Area of Science:
- Urology
- Anesthesiology
- Pharmacology
Background:
- Urethral pain during gel instillation is a common patient complaint.
- Lignocaine gel is frequently used to provide local anesthesia.
- The chemical components of lignocaine gel may contribute to discomfort.
Purpose of the Study:
- To investigate whether the chemical composition of lignocaine gel causes urethral pain.
- To compare patient-reported discomfort between plain aqueous gel and 2% lignocaine hydrochloride gel.
- To determine if a non-anesthetic gel reduces delivery discomfort.
Main Methods:
- Prospective, double-blind, randomized study.
- 100 male patients undergoing flexible cystoscopy were recruited.
- Patients received either 11 ml of 2% lignocaine hydrochloride gel or plain aqueous gel.
Main Results:
- Patients receiving plain aqueous gel reported significantly less urethral delivery discomfort.
- The difference in discomfort scores between the two groups was statistically significant (p=0.039).
- Plain gel demonstrated a superior safety profile regarding immediate urethral discomfort.
Conclusions:
- Plain aqueous gel causes significantly less discomfort during male urethral instillation than 2% lignocaine hydrochloride gel.
- The chemical content of lignocaine gel is likely a contributing factor to urethral pain.
- Consideration of non-anesthetic gels may improve patient comfort during urethral procedures.