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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[The expression of glucocorticold receptor isoform in peripheral blood mononuclear cell with Graves' ophthalmopathy]
Zhenmei An1, Nan Yu, Songquan Wei
1Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To study the expression of glucocorticoid receptor (GR) isoform in the peripheral blood mononuclear cell (PBMC) of patients with Graves' ophthalmopathy (GO).
Methods:
Semi-quantitative RT-PCR was used to analyze RNA isolated from PBMC of the patients with GO and the normal volunteers. The level of plasma total cortisol (PTC) at 8 a.m. was measured.
Results:
The hGR alpha/GR beta mRNA ratios of the two groups were 7.58 +/- 5.42 and 14.65 +/- 8.30, respectively. There was significant difference between the two groups (P < 0.05). The PTC levels of the two groups were 304.23 +/- 92.06 and 313.73 +/- 111.05, and no significant difference between them was noted (P > 0.05). No correlation was found between hGR alpha/GR beta mRNA and PTC levels.
Conclusion:
hGR alpha/GR beta mRNA may play a role in the pathogeny of Graves' ophthalmopathy.
