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[Adrenocortical tumors with neuroendocrine differentiation]
I A Kazantseva1, G A Poliakova, L G Gurevich
1Moscow Region Research Clinical Institute, 129110, Moscow.
Arkhiv Patologii
|February 11, 2003
Abstract:
18 adrenocortical tumours and 5 pheochromocytomas were studied immunohistochemically. Expression of synaptophysin and chromogranin A was found in cells of cortical adenomas, "frontier" neoplasms and in 20-75% of carcinoma cells, this ultramicroscopically was confirmed by observation of typical neuroendocrine granules. Some groups of cells of cortico-medullary tumours also expressed proteins of neural differentiation (protein S-100).