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Related Experiment Videos

Increased plasma ghrelin level in lung cancer cachexia.

Yoshito Shimizu1, Noritoshi Nagaya, Takeshi Isobe

  • 1The Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 11, 2003
PubMed
Summary

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Ghrelin levels were higher in lung cancer patients with cachexia. Post-chemotherapy anorexia also correlated with increased ghrelin, suggesting a compensatory role in this condition.

Area of Science:

  • Endocrinology
  • Oncology
  • Metabolism

Background:

  • Ghrelin, a growth hormone-releasing peptide, influences energy balance by stimulating appetite and promoting adiposity.
  • Lung cancer cachexia involves complex metabolic dysregulation.
  • Understanding ghrelin's role is crucial for managing cachexia in cancer patients.

Purpose of the Study:

  • To investigate the role and levels of ghrelin in lung cancer-associated cachexia.
  • To determine if ghrelin levels differ between cachectic and non-cachectic lung cancer patients.
  • To assess changes in ghrelin levels following chemotherapy in relation to food intake.

Main Methods:

  • Plasma ghrelin levels were measured in 43 lung cancer patients and 21 healthy controls.
  • Lung cancer patients were categorized into cachectic (n=21) and non-cachectic (n=22) groups.

Related Experiment Videos

  • Ghrelin levels were monitored pre- and post-chemotherapy, correlating with food intake.

    • Main Results:

    • Overall plasma ghrelin levels did not significantly differ between lung cancer patients and controls.
    • Significantly higher plasma ghrelin levels were observed in cachectic lung cancer patients compared to non-cachectic patients (180 vs. 135 fmol/ml, P=0.011).
    • Ghrelin levels increased significantly in patients experiencing decreased food intake after chemotherapy.

    Conclusions:

    • Elevated baseline plasma ghrelin is associated with cachexia in lung cancer.
    • Increased ghrelin levels post-chemotherapy correlate with anorexia, suggesting a compensatory mechanism.
    • Ghrelin may play a role in the catabolic-anabolic imbalance seen in lung cancer cachexia.