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Loss of anterior chamber-associated immune deviation during normal pregnancy in primates
1Research Section of Ophthalmology, Institute of Tissue Transplantation & Immunology, Jinan University, Guangzhou 510632, China.
Purpose:
We recently found that loss of anterior chamber-associated immune deviation was associated with normal pregnancy in rabbits. The purpose of this study is to further investigate whether the same events occurred in nonhuman primates.
Methods:
Mid-pregnant cynomolgus monkeys were randomly selected. Bovine serum albumin (BSA) was inoculated in anterior chamber of eyes of nonpregnant and mid-pregnant monkeys that were subsequently immunized with BSA in adjuvant. Delayed-type hypersensitivity (DTH) was assessed by skin challenge.
Results:
Non-pregnant monkeys of intracameral BSA proved able to acquire antigen-specific suppression of delayed-type hypersensitivity. By contrast, inoculation of BSA to anterior chamber of pregnant monkeys abolished the DTH-suppression effect.
Conclusions:
This is the first demonstration in primates that loss of anterior chamber-associated immune deviation occurred during normal pregnancy. The fluctuations of systemic hormone levels during normal pregnancy might influence local immunoregulation within the eye.