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[Interferon-alpha 2b inhibits proliferation of human tenon capsule fibroblasts]
1Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guang zhou 510060, China.
Purpose:
To evaluate the potential effect of interferon-alpha 2b(IFN alpha-2b) as antifibrotic treatment after glaucoma filtering surgery.
Methods:
The MTT method was used to study the inhibitory effect of IFN alpha-2b on human Tenon capsule fibroblasts in vitro. The antimetabolites including 5-fluorouracil (5-FU), homoharringtonine(H.H) and mitomycin C(MMC) were also assessed.
Results:
The IC50 values of IFN alpha-2b, 5-FU, H.H and MMC on fibroblasts at 48 hours were 60.578 mg/L, 5.447 mg/L, 0.531 mg/L, 1.329 mg/L respectively.
Conclusion:
The effect of IFN alpha-2b to inhibit proliferation of fibroblast was less than that of antimetabolites. Further investigation of other aspects of suppress(suppress) wound healing as a possible antifibrotic agent should be deserved.