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Genetic disorders and renal cell carcinoma
Jodi K Maranchie1, W Marston Linehan
1Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10/2B47, Bethesda, MD 20892, USA.
The Urologic Clinics of North America
|February 13, 2003
Abstract:
The study of hereditary RCC syndromes continues to provide significant insight into the pathways that are involved in renal cell tumorigenesis. The clinician should maintain a high level of suspicion for genetic disorders when patients present with early-onset or mult-focal RCC. Recognition of familial syndromes will facilitate the institution of parenchymal sparing measures, as well as appropriate screening and intervention for associated nonrenal manifestations.