Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Is tissue-engineered heart valve replacement clinically applicable?

Ronald C Elkins¹

¹Section of Thoracic and Cardiovascular Surgery, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA. ronald-elkins@ouhsc.edu

Current Cardiology Reports

|February 14, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Structural integrity of collagen and elastin in SynerGraft® decellularized-cryopreserved human heart valves.

Cryobiology·2011

Same author

Performance of the CryoValve SG human decellularized pulmonary valve in 342 patients relative to the conventional CryoValve at a mean follow-up of four years.

The Journal of thoracic and cardiovascular surgery·2010

Same author

Ross operation: 16-year experience.

The Journal of thoracic and cardiovascular surgery·2008

Same author

Total autologous Ross procedure in a child with aortic root abscess.

Journal of cardiac surgery·2006

Same author

Surgical management of valvular heart disease 2004.

The Canadian journal of cardiology·2006

Same author

Pulmonary autografts in patients with severe left ventricular dysfunction.

The Annals of thoracic surgery·2003

Same journal

Cardioimmunology of Myocarditis: Targeting the IL-1 Pathway.

Current cardiology reports·2026

Same journal

Antithrombotic Management in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation.

Current cardiology reports·2026

Same journal

Transcriptome Reprogramming in Heart Failure: The Hidden Splicing Code.

Current cardiology reports·2026

Same journal

Diagnosis and Management of Loeys-Dietz Syndrome: Evidence Gaps and Future Directions.

Current cardiology reports·2026

Same journal

Correction: Heart Disease in Older Women: Unique Challenges in Diagnosis and Management.

Current cardiology reports·2026

Same journal

Beyond the ICD: Navigating Ventricular Tachycardia Suppression Strategies in the Modern Era.

Current cardiology reports·2026

See all related articles

Tissue engineering advances heart valve repair using cell-seeded biodegradable stents or decellularized grafts. Clinical use of decellularized allografts is growing, but their long-term durability needs further study.

Area of Science:

Regenerative Medicine
Biomaterials Science
Cardiovascular Surgery

Background:

Heart valve tissue engineering offers promising alternatives to traditional valve replacement.
Current approaches include biodegradable stented valves and decellularized allografts/xenografts.

Purpose of the Study:

To review the progress and clinical application of different tissue-engineered heart valve strategies.
To highlight the expansion of decellularized allograft use and identify knowledge gaps.

Main Methods:

Preclinical evaluation and ovine implants were performed for each tissue engineering arena.
Clinical implantation data for decellularized grafts were analyzed.

Main Results:

Related Experiment Videos

Three main arenas of tissue engineering for heart valves have shown significant progress.

Clinical use is advancing for cell-seeded biodegradable valves and decellularized grafts (allografts and xenografts).

Conclusions:

Decellularized allografts that repopulate in vivo are increasingly used clinically.
The long-term durability and impact of this expanding clinical use on allograft performance remain undetermined.