Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SM047 immunoreactivity in peritoneal fluids.

W G McCluggage1, N H Anderson, A Patterson

  • 1Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK. glenn.mccluggage@bll.n-i.nhs.uk

Cytopathology : Official Journal of the British Society for Clinical Cytology
|February 18, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows.

Lab on a chip·2021
Same author

Prevalence of common mental disorders among Syrian refugee children and adolescents in Sultanbeyli district, Istanbul: results of a population-based survey.

Epidemiology and psychiatric sciences·2020
Same author

Correction to: Development of a new reproductive tissue cryopreservation clinical service for children: the Oxford programme.

Pediatric surgery international·2020
Same author

Development of a new reproductive tissue cryopreservation clinical service for children: the Oxford programme.

Pediatric surgery international·2019
Same author

ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2019
Same journal

Architectural Subtyping of Three-Dimensional Cell Groups in Bethesda III Thyroid Cytology: Distinguishing Spherules From Their Mimickers.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same journal

Cervical Cytokine Profile in High-Grade Squamous Intraepithelial Lesions.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same journal

COVID-19's Shadow: The Effect of COVID-19 on Cytopathology Specimens Received at an Academic Laboratory in Central South Africa.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same journal

Psammoma Bodies in Cervical Liquid-Based Cytology of a Kyleena User.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same journal

The Diagnostic Yield of Fine Needle Aspiration and Biopsy Needles According to Needle Passes Number in Diagnosing Pancreatic Adenocarcinoma.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
Same journal

Challenges in Diagnosing Isolated Rib Metastasis From Low-Grade Endometrial Carcinoma: Utility of USG-FNAC and Molecular Characterisation.

Cytopathology : official journal of the British Society for Clinical Cytology·2026
See all related articles

SM047 monoclonal antibody shows high accuracy in diagnosing ovarian serous adenocarcinoma in peritoneal fluid samples. Negative SM047 staining helps rule out ovarian cancer and suggests colorectal adenocarcinoma.

Area of Science:

  • Oncology
  • Immunohistochemistry
  • Cytopathology

Background:

  • Ovarian serous adenocarcinoma is a significant cause of cancer-related mortality.
  • Accurate diagnosis in peritoneal fluid cytology is crucial for patient management.
  • SM047, a monoclonal antibody, shows promise in identifying ovarian cancer cells.

Purpose of the Study:

  • To evaluate the diagnostic utility of SM047 antibody staining in peritoneal fluid cytology.
  • To determine if SM047 can differentiate ovarian serous adenocarcinomas from other malignancies and reactive mesothelial cells.

Main Methods:

  • Immunocytochemical staining of 206 consecutive peritoneal fluid samples using SM047.
  • Comparison with established markers including CA125, mCEA, Ber-EP4, CK7, and CK20.

Related Experiment Videos

  • Analysis of SM047 expression in ovarian serous adenocarcinomas, other adenocarcinomas, mesotheliomas, and benign mesothelial cells.

    • Main Results:

    • SM047 demonstrated high sensitivity (96%) for ovarian serous adenocarcinomas.
    • SM047 was positive in reactive mesothelial cells (83%) but negative in colorectal adenocarcinomas.
    • Distinct staining patterns were observed for SM047, Ber-EP4, and CK20 differentiating tumor types.

    Conclusions:

    • SM047 is a valuable marker for diagnosing ovarian serous adenocarcinoma in peritoneal fluids.
    • Negative SM047 staining is indicative of colorectal adenocarcinoma, aiding differential diagnosis.
    • SM047, as part of a panel, can improve the work-up of peritoneal effusions.