Related Experiment Videos
Magnetization transfer MR imaging in patients with posttraumatic epilepsy
Rajesh Kumar1, Rakesh K Gupta, Mazhar Husain
1Department of Radiology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, UP, India 226014.
AJNR. American Journal of Neuroradiology
|February 20, 2003
Summary
Magnetization transfer (MT) MR imaging can predict intractable epilepsy after head trauma. Gliosis around hemosiderin deposits, identified via MT imaging, is linked to seizure intractability in patients with posttraumatic epilepsy.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Intractable epilepsy is a known complication of head trauma.
- Pathogenesis involves multiple factors, including tissue damage.
- Assessing tissue damage severity is crucial for understanding epilepsy development.
Purpose of the Study:
- To determine the severity of tissue damage after severe head injury using magnetization transfer (MT) MR imaging.
- To investigate the relationship between tissue damage severity and seizure intractability.
Main Methods:
- Forty-four patients (31 with seizures, 13 controls) underwent T1-weighted MT MR imaging 1-10 years post-trauma.
- Phase-corrected gradient-echo (GRE) imaging was used to detect hemosiderin.
- Evaluation included MT abnormalities beyond or within T2 abnormalities and hemosiderin deposition.
Main Results:
- MT abnormalities extending beyond T2 lesions were significantly associated with higher seizure intractability (P < .05).
- Hemosiderin presence alone did not correlate with seizure intractability.
- Gliosis around hemosiderin, visualized by T1-weighted MT imaging, was linked to seizure intractability.
Conclusions:
- T1-weighted MT imaging shows potential for predicting seizure intractability in delayed posttraumatic epilepsy.
- MT imaging can help identify patients at higher risk for intractable seizures post-head injury.